MAP3K8 and neoplasm: As we observed a significant association between MAP3K8 protein levels and patient's response to treatment (Fig. 1d, right panel), we first validated that observation regarding P-MEK in the TCGA cohort of HGSC patients (http://cancergenome.nih.gov/; P-MEK status available in reverse-phase protein array data for 412 tumour samples, as well as primary therapy outcome, as defined in TCGA).