Higher levels of markers of systemic inflammation were associated with an increased incidence of CS-CLD (ln C-reactive protein hazard ratio (HR) 1.66 P = 0.026, ln IL-6 HR 2.86 P = 0.002, ln TNF-α HR 2.12 P = 0.017). Here, TNF is linked to congenital secretory chloride diarrhea 1.