Moreover, there is increasing evidence that MYC protein over-expression may occur in tumors without apparent gene alterations [15] and it has been suggested that a dysregulated expression of microRNAs (miRNAs) may represent one of the mechanisms leading to MYC overexpression in BL cases lacking a classical MYC translocation, through either a direct or indirect mechanism [5, 6]. This evidence concerns the gene MYC and Burkitt lymphoma.