ALS associated with TDP-43 positive inclusions (ALS-TDP) and frontotemporal lobar degeneration with TDP-43 positive inclusions (FTLD-TDP) (a pathological process associated with frontotemporal dementia, semantic dementia and/or progressive non fluent aphasia) are believed to represent a clinicopathological spectrum, where some patients have clinical and pathological features of a frontotemporal dementia and ALS (FTLD-MND/ALS). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.