Previous studies have highlighted that NAV2 was abundantly expressed in 16 of 20 colon cancers examined but hardly detectable in corresponding non-cancerous mucosae using semi-quantitative RT-PCR, NAV2 showed 3’ to 5’ helicase activity and exonuclease activity in vitro as an oncogene. The gene discussed is NAV2; the disease is malignant colon neoplasm.