VEGFA and colorectal cancer: The current National Comprehensive Cancer Network (NCCN) guideline recommends a systemic chemotherapy regimen comprising a FOLFOX/FOLFIRI/FOLFOXIRI (folinic acid (leucovorin (LV)), 5-fluorouracil (5-FU), and oxaliplatin/irinotecan) regimen plus molecular-target treatments (an anti-vascular endothelial growth factor, anti-epidermal growth factor receptor, aflibercept, or anti-multi-kinase antibody therapy) for unresectable/recurrent colorectal cancers [5].