For example, ipsilateral tumour pair 1 showed highly similar methylation patterns, where all the genes that were methylated in the primary tumour were also methylated in the second tumour with additional methylation in TP73. On the other hand, contralateral pair 2 showed methylation of CDH13, MAL and TWIST1 in the first tumour but no methylation of any of the marker panel was found in the second tumour. Here, MAL is linked to neoplasm.