H6PD and polycystic ovary syndrome: Although previous genetic studies reported a significant association between H6PD polymorphisms and the phenotype of PCOS [10, 22, 23], a case-control study in 2011 using DNA samples from 74 patients with PCOS and 31 healthy controls indicated that the H6PD gene coding variants rarely (<1.5%) were responsible for hyperandrogenemic PCOS [24].