HSD11B1 and hyperandrogenism: No significant difference was found between clinical parameters and rs17368528 in H6PD and rs846908 in HSD11B1. Then we divided patients into two groups by testosterone level to evaluate the distribution of the three genotypes, we also found a significant difference between AA and AG genotype of rs6688832 and the AG genotype was associated with hyperandrogenism, but no statistical different distribution of polymorphism rs17368528 of H6PD and rs846908 of HSD11B1 were observed.