Pathological grading of 1566 pancreatic lobes from Hras+/+ KC mice and 1544 pancreatic lobes from Hras-/- KC mice revealed 18.7% more lobes with no lesions and a trend towards more PanIN 1A lesions in Hras-/- KC mice (Fig 3D). This evidence concerns the gene HRAS and keratoconus.