CBS and cancer: Since P53 mutation is near universal in high grade serous ovarian cancer [33], we have chosen three different types of cancer cell lines having different p53 background to demonstrate functional significance of CBS and SREBPs in lipid metabolism in ovarian cancer, namely, A2780 (expresses only wild-type p53 [34]), SKOV3 (does not express p53 mRNA or protein [35]) and OVCAR4 (expresses mutated p53 [36]).