Recently Nomura et al. reported a specific lipid signature that was associated with overexpression of monoglyceride-lipase (MAGL), a lipase involved in releasing free fatty acids (FFAs) from triacylglycerols (TAGs) and its overexpression was found in highly aggressive cancers and its inhibition caused defects in cancer cell migration and tumor growth [14]. The gene discussed is MGLL; the disease is cancer.