However, no significant effect of MAGI3 expression on JNK signaling was observed in glioma, as determined by GSEA of the correlation between the expression levels of MAGI3 and genes in the JNK pathway in glioma clinical samples (GEO # GSE4412) (FDR = 0.73, Supplementary Figure S5). Here, MAPK8 is linked to central nervous system cancer.