MAGI3 and central nervous system cancer: To investigate the biologic effects of MAGI3 in glioma, C6 cells, which express moderate levels of endogenous MAGI3, were stably transfected with GFP-MAGI3, whereas U373 and LN229 cells, which express relatively high levels of endogenous MAGI3, were respectively transfected with two different MAGI3 siRNAs.