Surprisingly, we find that rather than the canonical 69 KDa isoform of ST6GalNAc1, a novel ∼55KDa protein isoform of the ST6GalNAc1 protein isoform is instead induced by androgens in prostate cancer cell lines in vitro, and also expressed in clinical prostate tissue. The gene discussed is ST6GALNAC1; the disease is prostate carcinoma.