In an independent dataset of 88 individual neuroblastoma tumors (NCBI GEO Accession No. GSE 16476;http://www.ncbi.nlm.nih.gov/geo/), we found PRAME (also known as MAPE) to be significantly expressed in high-risk neuroblastoma tissues (Fig. 2A). The gene discussed is PRAME; the disease is neuroblastoma.