The strongest evidence for a functional role of sperm RNA in the transmission of non-Mendelian epigenetic inheritance comes from the experiments in which injection of specific RNAs into the fertilized egg leads to the reproducible induction of phenotypes ranging from the white tail Kit-mediated trait [1, 6], to cardiac hypertrophy [2], prenatal and postnatal overgrowth [3], and stress-induced behavioral and metabolic alterations [5]. The gene discussed is KIT; the disease is cardiac hypertrophy.