Additionally, we demonstrated that CSCs, when engrafted orthotopically in the bladder, developed a phenotypically heterogeneous tumor resembling the clinical and histological features of primary invasive BC; under these conditions, a minority of cells expressing markers of undifferentiated cells including SOX2, ALDH2 and CD47, was observed, together with an expanded population of proliferating differentiated cells. Here, CD47 is linked to breast cancer.