KEAP1 and hepatocellular carcinoma: Notably, our very recent data obtained in the R-H model showed that activation of NRF2/KEAP1 pathway, due either to down-regulation of miRNA-200a, which targets KEAP1, or to extremely frequent missense mutations of NRF2, characterizes preneoplastic nodules and persists all throughout the process up to HCC development [48].