In a recent study, Govaere et al. [24] demonstrated that in vitro primary human CK-19-positive tumor cells showed increased invasiveness and that CK-19 knockdown significantly reduced HCC invasive ability and rendered HCC cells more sensitive to cytotoxic agents, such as doxorubicin, 5-fluorouracil and sorafenib. The gene discussed is KRT19; the disease is neoplasm.