Using multivariate analysis, high CHI3L1 expression (HR: 2.91, 95% CI: 1.89 − 4.48, p < 0.001), advanced stage (HR: 2.47, 95% CI: 1.24 − 4.90, p = 0.009), high-grade (HR: 1.73, 95% CI: 1.01 − 2.97, p = 0.044) and residual tumor size > 1 cm after debulking surgery (HR: 1.74, 95% CI: 1.18 − 2.57, p = 0.005) were independent risk factors for recurrence. Here, CHI3L1 is linked to neoplasm.