In contrast, the tumor with a very high SUV of 10.5 carries two potentially harmful mutations in two mitochondrial tRNAs, has average COX1 levels (Supplementary Figure S3B) and very low levels of NDUF-S1 (complex I, Figure 3B), a situation typical for cells carrying inactivating mitochondrial tRNA mutations [38, 39], since complex I has seven mtDNA encoded subunits. This evidence concerns the gene NDUFS1 and neoplasm.