HES1 and nasopharyngeal carcinoma: Briefly, high expression of Hes1 was more frequently observed in T3-T4, N2-N3, M1, and III-IV tumors than T1-T2, N0-N1, M0, and I-II tumors, suggesting that Hes1 overexpression correlated with aggressive phenotypes of NPC and may be involved in the invasion and metastasis of NPC (Figure 1C, 1D and Table 1).