HES1 and neoplasm: While metastatic tumors on lung surface derived from vector- or Hes1-expressing CNE2 cells were not detected under a dissection microscope (Figure 4C), histological examination identified an average of 23.3 ± 23.1 metastatic tumor nodules on lung surface in three of eight mice received CNE2-vector transplant (Figure 4D, 4E, 4F).