On the contrary, Hes1 expression was associated with the tumor size (T classification) (P = 0.018), lymph node invasion (N classification) (P = 0.006), metastasis (M classification) (P = 0.021), and clinical stage (P = 0.001) of 103 NPC patients (Table 1). This evidence concerns the gene HES1 and nasopharyngeal carcinoma.