By conducting genome-wide DNA methylation profiling in 202 pediatric glioblastomas, Korshunov and colleagues identified an epigenomic subset of glioblastoma showing methylation pattern similar to pleomorphic xanthoastrocytoma, enriched for BRAF mutation and CDKN2A homozygous deletion, and showed favorable prognosis [9]. The gene discussed is CDKN2A; the disease is pleomorphic xanthoastrocytoma.