Young adult glioblastomas with BRAF, IDH1, H3F3A-G34R/V mutations and EGFR amplification predominantly developed in hemispheric locations without affecting midline structure, with the exception of one BRAF mutated glioblastoma in corpus callosum and three IDH1 mutated glioblastomas in basal ganglia (one case) and corpus callosum (two cases). This evidence concerns the gene IDH1 and glioblastoma.