Many studies have investigated the presence of p53-AAbs in ovarian cancer for a diagnostic purpose [17], as well as in other types of cancers [18], suggesting its potential role as a screening biomarker especially in association with: 1) other early ovarian tumour markers, i.e. Carbohydrate Antigen 125 (CA-125) and Human Epididymis Protein 4 (HE4), to increase early diagnostic sensitivity; 2) imaging/radiological screening in high-risk populations [19, 20]. Here, TP53 is linked to ovarian neoplasm.