We found that the gene pairs from both datasets had significantly higher SINaTRA scores (Syn-Lethality: U = 12,265, p<2.2e-16; DAISY (VHL): U = 299, p = 5.86e-6; DAISY (cancer): U = 1992856, p<2.2e-16; Fig 2E). This evidence concerns the gene VHL and cancer.