ACSL4 and colorectal carcinoma: Moreover, the multivariable model x3 (combined expression of ACSL1, ACSL4 and SCD) showed that the simultaneous overexpression of the ACSL/SCD network resulted in a stronger and more potent association with patient relapse (Figure 4D and Table 1), confirming the acquisition of increased aggressive properties of CRC tumors with these characteristics.