STK11 and cancer: Interestingly, other miRNAs of the MSC signature behave as general sensors of metabolic and stress related pathways such a mir-451 [28], a sensor of glucose levels which regulates LKB1/AMPK signaling and allows adaptation to metabolic stress and mir-486-5p, a cardiac/skeletal muscle enriched miRNA whose reduced expression in plasma may reflect cancer-induced skeletal muscle dysfunction and cachexia [29].