EGFR receptors include AR, EGF, TGF-α, epiregulin, heparin-binding EGF (HB-EGF) and Hepatocarcinoma cell-derived hepatoma-derived growth factor (HDGF), have been confirmed to mediate tumorigenesis and promote tumor progression [50, 51]. The gene discussed is HBEGF; the disease is neoplasm.