To date, four different genes ZEB1 (10p11.22, MIM∗189909), AGBL1 (15q25.3, MIM∗615496), LOXHD1 (18q21.1, MIM∗613072), and SLC4A11 (20p13, MIM∗610206) as well as four causal loci on chromosomes 5q33.1–q35.2 (FCD3), 9p22.1–p24.1 (FCD4), 13pter-q12.13 (FCD1), and 18q21.2–q21.32 (FCD2), together with a number of susceptibility loci, have been implicated in the pathogenesis of FECD (summarized in Table 1) [7, 8]. This evidence concerns the gene TCF4 and Fuchs endothelial corneal dystrophy.