Our studies using 2 pancreatic cancer cell lines adapted for in vitro cell culture provide a potential scenario of how Ocln co-localization with c-Yes, YAP, and TEAD might function as a sensor system for Hpo pathway signaling and build upon the previously established status of c-Yes as a bona fide binding partner of YAP and Ocln (Nusrat et al., 2000). Here, OCLN is linked to familial pancreatic carcinoma.