Increased MMP-9 expression/activity in the retina was reported upon induction of ischemia-reperfusion injury [11, 13–16], N-methyl-D-aspartic acid (NMDA) and kainic acid-mediated excitotoxicity [10, 12], optic nerve transection [17], and ocular hypertension [18] in rodents. The gene discussed is MMP9; the disease is ocular hypertension.