PBK and acute myeloid leukemia: To provide insights into the molecular mechanism by which TOPK inhibition results in stronger growth suppression in FLT3-ITD mutated AML cells in comparison to FLT3-wt AML cells, we performed gene expression microarray analysis in FLT3-ITD mutated MV4-11 cells transfected with TOPK-siRNA or treated with OTS514, compared with control MV4-11 cells.