AKT1 and cancer: This form of RXRα is generated by cleavage of the full length RXRα by calpain II and was shown to be responsible for high cancer cell proliferation in vitro and in vivo through phosphorylation and activation of Akt [9, 10] Here, we showed that cells with high expression of t-RXRα present a predominantly cytoplasmic LXRβ localization and a greater sensitivity to LXR ligand-induced cell death.