TARDBP and early-onset autosomal dominant Alzheimer disease: This include the misfolding of mutant huntingtin (mHTT) in Huntington’s disease (HD), tau in Alzheimer’s disease (AD), α-synuclein in Parkinson’s disease, and TAR DNA-binding protein 43 (TDP-43) in amyotrophic lateral sclerosis (ALS)1, 2.