For example, FZD8 and FOXN1 are commonly linked to 14 genes in Fig. 6c, among which TGFBI has been proved to contribute to Allergic asthma [47] and T2D [50], CCL18 contributes to Allergic asthma [51] and GHR is associated with T2D [52]. This evidence concerns the gene TGFBI and type 2 diabetes mellitus.