Still taking Crohn’s disease and its therapeutic drug, infliximab, as an example, Crohn’s disease is negatively connected with T-cell source of chronic lymphocytic leukemia (correlation coefficient −0.15, at top 5 %) and Melanoma (correlation coefficient −0.05, at top 50 %) in our data; infliximab, a chimeric monoclonal antibody against tumor necrosis factor alpha (TNF-α), is usually used for treatment of inflammatory bowel disease (IBD) such as Crohn’s disease [53]. Here, TNF is linked to Crohn disease.