The SAFETY study recently determined that (1) cut-off values are set too high for reliable detection of pediatric chronic liver disease (In fact, hepatic steatosis was detectable at ALT values 10–50 % lower than conventional thresholds (25 U/L vs 30–66 U/L)) and (2) that these lower cut points are sensitive and specific to detecting liver diseases, including NAFLD, in children and adolescents [9]. The gene discussed is GPT; the disease is fatty liver disease.