Differentially down-regulated genes in IGF1-R-high T-ALL patients were enriched in the categories induction of apoptosis (P-value = 0.02) and induction of programmed cell death (P-value = 0.02), the most functionally established being pro-apoptotic gene BCL2L11 (Table 2). This evidence concerns the gene IGF1R and acute lymphoblastic leukemia.