Our results may also help clarify the etiology of the altered snouts of mice with mutations in genes known to affect resorption such as Mmp2 (Egeblad et al., 2007), and jaw length defects in humans with conditions such as Juvenile Paget’s disease (i.e., Opg) and Spondyloepimetaphyseal dysplasia (i.e., Mmp13) (Gorlin et al., 1990; Lezot et al., 2014). Here, MMP13 is linked to juvenile Paget disease.