In addition, even if human studies show contradictory results, it seems that the IGF1R prognostic value also depends on the tumor ER status: in ER-positive mammary carcinomas, IGF1R overexpression is related to a favorable prognosis [18, 19] as opposed to the triple-negative subtype, in which IGF1R overexpression is associated with a poor outcome [18, 19, 40]. The gene discussed is IGF1R; the disease is breast carcinoma.