IGF1R expression is highly related to prognosis in breast cancer, with a prognostic value dependent on the ER status of the tumors: in ER-positive breast cancer, IGF1R overexpression is related to favorable outcome [18] as opposed to ER-negative carcinomas, in which IGF1R overexression is associated with a poor outcome [19]. The gene discussed is IGF1R; the disease is breast cancer.