CXCL8 and central nervous system cancer: Among these, the NF-kappaB network should be carefully considered for the following reasons: (a) NF-kappaB is one of the major transcription factors involved in IL-8 gene regulation [18]; (b) NF-kappaB is a marker of glioma onset and progression [12, 13, 52, 53]; (c) miR-16 inhibits glioma cell growth through suppression of the NF-kappaB signaling pathway [54].