Interestingly, the IL-8 and VEGF staining was found mainly associated with the areas showing hypoxic features and most frequently in those astrocytic spindle cells characterizing the “pseudopalizading” pattern, observed in the areas in proximity to hypoxia and hypoxic necrosis, which represents a histological hallmark of the glioblastoma. The gene discussed is CXCL8; the disease is glioblastoma.