PTPMT1 and type 2 diabetes mellitus: Consistently, carriers of the risk allele at rs1055144 had higher methylation levels in the promoter of MIR148A. Also, carriers of the risk allele at rs10838738 had lower methylation in the promoter of PTPMT1, a gene that codes for a mitochondrial phosphatase whose inhibition lowers glucose concentration [75] and a suggested drug target for treatment of type II diabetes [76].