It is intriguing to consider whether correlations of PQS abundance/location with transcriptional sensitivity to RecQ helicase loss observed in this study may similarly be found for other DNA helicases such as the RecQ4 helicase (deficient in Rothmund-Thomson photosensitivity- and cancer-associated syndrome), FANCJ helicase (deficient in Fanconi Anemia), and RecQ1 and RecQ5 helicases (members of the RecQ helicase family, but lacking evidence of a human phenotype). The gene discussed is RECQL; the disease is Fanconi anemia.