Although many genes exhibited high editing rate in terms of number of events per locus, RBFOX1 appeared the most edited comprising 142 Alu elements and coding for a RNA-binding protein able to interact with the ataxin-2 which is involved in the familial form of spinocerebellar ataxia type 2 (SCA2). This evidence concerns the gene RBFOX1 and spinocerebellar ataxia type 2.