Consistent with a previous report [20–21], we found that GFAP-positive cells (astrocytes), Iba1-positive cells (microglia), and iNOS were elevated in the AD mouse model, while SB271046 attenuated the expression of GFAP, Iba1, and iNOS (Figure 2D-2F). Here, GFAP is linked to Alzheimer disease.