SERPINE1 and obesity due to melanocortin 4 receptor deficiency: Consistently, it has been observed that MR antagonism in vivo can reverse the expression of obesity-related inflammatory genes in adipose tissue, such as Tnfα, Mcp1, Cd68, and plasminogen activator inhibitor-1 (Pai1) and promote the expression peroxisome-proliferator activated receptor gamma (Pparγ) and adiponectin [83, 84].