For example, 76% rheumatoid arthritis (RA) patients treated during two weeks with spironolactone plus the individual treatment responded favorably to therapy according to American College of Rheumatology criteria, mainly due to lower systemic levels of TNF-α, IL-6, GM-CSF, and IFN-γ after the treatment [69]. The gene discussed is TNF; the disease is rheumatoid arthritis.