NR3C2 and hypertensive disorder: Primary cultures of murine peritoneal macrophages from MyMRKO showed that loss of MR activation drives these cells towards an alternative activation, measured by gene expression [25]. In vivo experiments made in MyMRKO mice, but in the hypertensive model mediated by angiotensin II/L-NAME, did not show protection to develop hypertension but presented reduced signs of aortic fibrosis and hypertrophy.