REN and Hypertension resistant to conventional therapy: As PA patients also present more cardiovascular complications, such as left ventricular hypertrophy [108, 109], stroke, nonfatal myocardial infarction, and atrial fibrillation [105], the increase in the aldosterone-renin ratio in resistant hypertension patients has been used as a predictor of exacerbated cardiovascular injury and increases the risk of developing uncontrolled resistant hypertension [110].