Increased incidence of PsP has been proven by several authors especially in tumors with hypermethylation of the O(6)-methylguanine-DNA methyltransferase (MGMT) promoter gene [6] confirming greater activity of the combined treatment in this subset of patients with a favorable prognosis and longer progression and survival times [21]. Here, MGMT is linked to supranuclear palsy, progressive, 1.