There was a significant difference in nodal stage between the patients with a BRAF-positive largest tumor and a BRAF-negative largest tumor: 11 of the 16 patients (69%) with a BRAF-positive largest tumor had cervical lymph node metastases (either N1a or N1b) compared to 2 of the 11 patients (18%) with a BRAF-negative largest tumor (P = 0.02). The gene discussed is BRAF; the disease is neoplasm.