VHL was mapped as a ubiquitous driver mutation in 64–100% of ccRCC tumours analysed by Gerlinger et al. and Sankin et al. [95, 96]. BAP1, PBRM1, SETD2, and KDM5C mutations were found in different subclones in the same tumour, indicating that these were later mutations [95, 96]. This evidence concerns the gene KDM5C and nonpapillary renal cell carcinoma.