TNF and cancer: SiRNA-mediated inhibition of MALAT-1 and HOTAIR suppresses cancer cell viability and invasion, sensitizes TNF-α, induces apoptosis, and increases chemotherapeutic sensitivity of HCC to cisplatin and doxorubicin [82, 83]. HOTTIP (HOXA transcript at the distal tip) and HOXA13 were also found to be upregulated in HCC. HOTTIP and HOXA13 levels were associated with HCC tumor progression, metastasis, and survival [84]. HEIH (high expression in HCC) is another lncRNA overexpressed in HCC and an independent prognostic factor associated with recurrence [85].