This results in p15/INK4b, p14/ARF, and p16INK4a inhibition which are normally implicated in cell cycle negative regulation, senescence, and stress-induced apoptosis. ANRIL overexpression in prostate carcinomas has shown silencing of INK4b-ARF-INK4a and p15/CDKN2B. This evidence concerns the gene CDKN2A and prostate carcinoma.