Conversely, a recent study focusing on 348 primary breast carcinomas revealed that increased DNA methylation led to HOTAIR downregulation and an unfavorable disease state, questioning suitability of HOTAIR as negative prognostic biomarker in breast carcinomas [31]. LincRNA-RoR suppresses p53 in response to DNA damage through interaction with heterogeneous nuclear ribonucleoprotein I (hnRNP I). This evidence concerns the gene HOTAIR and breast carcinoma.