Galectin-1, galectin-3, and their binding protein 90K/Mac-2BP are reported to be correlated and modulated with the malignancy prognosis and distal metastasis of colon cancer [2–4], but clinically the correlation between these serum galectins and prognosis of patients with colorectal cancer is less studied, especially 90K/Mac-2BP. Here, LGALS3 is linked to colorectal cancer.