LGALS3 and cancer: Some galectins (such as galectin-1 and galectin-3) and their binding proteins such as 90K/Mac-2BP are reported to be correlated with the malignancy prognosis and distant metastasis of colon cancer [2–4, 10–12]; Nakamura et al. had clarified that strong expression of galectin-3 in colorectal cancer correlated with cancer progression, liver metastasis, and poor prognosis [13].