In contrast, Lee et al. clarified that 90K/Mac-2BP itself has antitumor activity in CRC cells via suppression of Wnt signaling with a novel mechanism of ISGylation-dependent ubiquitination of beta-catenin when it interacts with CD9/CD82 but is downregulated in advanced CRC tissues [20]. The gene discussed is CTNNB1; the disease is colorectal carcinoma.