LGALS3 and colonic neoplasm: Galectin-3 was a cytosolic and secretary protein but was less detected in the extracellular medium during primary cancer cell culture [17], indicating that cancer cells alone do not secrete galectin-3 into extracellular medium and this could be the reason why the present result, serum galectin-3, was not correlated with prognosis of colon cancer.