Thijssen et al. showed that galectin-3 expression on epithelium of colon cancer was unaltered [16] and Sanjuán et al. found that galectin-3 expression is downregulated in the initial stages of neoplastic progression, whereas a dissociated cytoplasmic expression increases in later phases of tumor progression [3]. The gene discussed is LGALS3; the disease is colonic neoplasm.