Analysis of Receiver Operating Characteristic (ROC) curves of galectins and CEA concentrations for CRC with LN metastasis found that galectin-1 and CEA levels could predict lymph node metastasis at good sensitivity and specificity, showing area under the curve (AUC) at 0.627 for galectin-1 and at 0.638 for CEA (Figure 5(b)). Here, LGALS1 is linked to metastatic malignant neoplasm in the lymph nodes.