In the study by Bax et al. phosphorylated receptor tyrosine kinase profiling showed a specific activation of platelet-derived growth factor receptor (PDGFR) α/β in EGFRvIII-transduced pediatric GBM cells and targeted coinhibition with erlotinib and imatinib, an inhibitor of the tyrosine kinases Bcr-Abl, Kit, and PDGFR, could lead to enhanced efficacy [26]. The gene discussed is PDGFRB; the disease is glioblastoma.