In pediatric HGGs available data suggest that EGFR amplification occurs with low frequency, averaging about 3% [11, 25], although in a recent study Bax et al. found a greater prevalence of EGFR gene amplification and EGFRvIII mutation in pediatric HGG than had previously been recognized [26]. EGFRvIII is the most common mutant of EGFR gene reported in GBM. This evidence concerns the gene EGFR and glioblastoma.