MKI67 and adenocarcinoma: Ki-67 protein, when used to evaluate the percentage of dividing cells, allows us to determine neoplastic growth [21] and has been documented to correlate with neoplastic progression [22] showing different levels of expression between normal mucosa, adenoma, and adenocarcinoma [23], verifying a progressive increasing of positive Ki-67 expression from the first (normal mucosa) to the last part of the tissue (adenocarcinoma) [22, 24, 25].