With regard to Ki-67 index in lymph node metastasis, as far as we know, this is the first study realized in CRC and, the more similar that we found in literature is the study of Yamauchi et al. [41], which compares Ki-67 index in primary CRC tumours with the respective nodules of peritoneal metastization. This evidence concerns the gene MKI67 and metastatic malignant neoplasm in the lymph nodes.