In CRC, the analysis of colon adenomas has shown a different pattern for Ki-67 expression between normal tissue, adenomas, and adenocarcinomas, being limited to the crypts in normal tissue and expressed both in the crypts and in the surface epithelium in adenomatous polyps (tubular, villous) [31] and distributed homogeneously in adenocarcinoma [32]. The gene discussed is MKI67; the disease is adenocarcinoma.