The enhanced CCL2 expression has been associated with the progression of the CNS pathology in two clinically distinct mouse models of MS, i.e. Theiler's murine encephalomyelitis virus-induced demyelinating disease and relapsing-remitting EAE [58], and the development of relapse of autoimmune encephalomyelitis in Lewis rats [59]. This evidence concerns the gene CCL2 and demyelinating disease.